So where to begin a 4,500 mile road trip? I thought about doing the straight East West route following US-20 from New York to Portland but thanks to the magic of google maps and street view, you can get a pretty good picture of what the scenery might be like and unless you're a (modern) history buff or dig the East Coast scene, it's kind of short on the spectacular for my taste.
To go chasing mountains and landscape you have to head West to the North American parts of the American Cordillera (read all about it in the riveting Lithotectonic terrain map of the North American Cordillera by Silberling, N.J. et al. 1992)
, comprising the Rocky Mountains, Sierra Nevada, Cascades and Coast ranges of Oregon, Washington and California.